Journal article
Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway
Abstract
AIMS: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17β-estradiol and it can bind to the estrogen receptor. Here, we hypothesized that Tanshinone IIA might have anti-inflammatory and anti-oxidative effects in atherosclerosis, mediated through estrogen receptor activation.
METHODS: Subjects for this study were 120 apoE(-/-) female …
Authors
Liu X; Guo C-Y; Ma X-J; Wu C-F; Zhang Y; Sun M-Y; Pan Y-T; Yin H-J
Journal
Cellular Physiology and Biochemistry, Vol. 35, No. 5, pp. 1744–1755
Publisher
Karger Publishers
Publication Date
2015
DOI
10.1159/000373986
ISSN
1015-8987
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AbietanesAnimalsAnti-Inflammatory Agents, Non-SteroidalApolipoproteins EAtherosclerosisDiet, High-FatDisease Models, AnimalEstradiolEstrogensExtracellular Signal-Regulated MAP KinasesFemaleMiceMice, Inbred C57BLMice, KnockoutNF-kappa BOvariectomyOxidative StressReceptors, EstrogenSignal TransductionSuperoxide DismutaseTriglycerides