Journal article
Pertuzumab Cardiotoxicity in Patients With HER2-Positive Cancer: A Systematic Review and Meta-analysis
Abstract
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) overexpressing malignancies, including breast and gastro-esophageal, are associated with a poor prognosis. The cardiotoxicity of trastuzumab, a HER2-targeting monoclonal antibody, is well established. However, the cardiotoxic effect of pertuzumab, another HER2-directed therapy, is less well documented. The objective of this systematic review and meta-analysis was to determine the risk …
Authors
Alhussein MM; Mokbel A; Cosman T; Aghel N; Yang EH; Mukherjee SD; Dent S; Ellis PM; Dhesy-Thind S; Leong DP
Journal
CJC Open, Vol. 3, No. 11, pp. 1372–1382
Publisher
Elsevier
Publication Date
November 2021
DOI
10.1016/j.cjco.2021.06.019
ISSN
2589-790X