Journal article
Distribution of Cell-Free and Cell-Associated HIV Surrogates in the Female Genital Tract After Simulated Vaginal Intercourse
Abstract
BACKGROUND: Rational development of drugs to prevent human immunodeficiency virus (HIV) transmission benefits from an understanding HIV distribution in the female genital tract after intercourse. This study describes HIV distribution using surrogates of cell-free and cell-associated HIV and semen.
METHODS: Apheresis-derived, autologous, lymphocyte-rich cells radiolabeled with 3.7-MBq (100-μCi) indium 111 ((111)In)-oxine (cell-associated HIV …
Authors
Louissaint NA; Fuchs EJ; Bakshi RP; Nimmagadda S; Du Y; Macura KJ; King KE; Wahl R; Goldsmith AJ; Caffo B
Journal
The Journal of Infectious Diseases, Vol. 205, No. 5, pp. 725–732
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2012
DOI
10.1093/infdis/jir841
ISSN
0022-1899