Journal article
18F-XTRA PET for Enhanced Imaging of the Extrathalamic α4β2 Nicotinic Acetylcholine Receptor
Abstract
Reduced density of the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) in the cortex and hippocampus of the human brain has been reported in aging and patients with neurodegenerative disease. This study assessed the pharmacokinetic behavior of 18F-(-)-JHU86428 (18F-XTRA), a new radiotracer for in vivo PET imaging of the α4β2-nAChR, particularly in extrathalamic regions of interest in which the α4β2-nAChR is less densely expressed than in …
Authors
Coughlin JM; Slania S; Du Y; Rosenthal HB; Lesniak WG; Minn I; Smith GS; Dannals RF; Kuwabara H; Wong DF
Journal
Journal of Nuclear Medicine, Vol. 59, No. 10, pp. 1603–1608
Publisher
Society of Nuclear Medicine
Publication Date
October 2018
DOI
10.2967/jnumed.117.205492
ISSN
0161-5505