6.1 STUDY OF ALTERED NEUROIMMUNITY IN PSYCHOSIS USING PET-BASED IMAGING OF THE TRANSLOCATOR PROTEIN 18 KDA: PROMISES, PITFALLS, AND FUTURE DIRECTIONS

Successful development of high affinity radioligands for the translocator protein 18 KDa (TSPO) has contributed to a rapid rise in their use with positron emission tomography (PET) imaging to quantitatively detect the higher density of TSPO in neuropsychiatric conditions with putative microglial activation or reactive gliosis in vivo. [11C]PK11195 has been widely used to study TSPO in many neurological and psychiatric diseases, but the quality …