Journal article
Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients
Abstract
BackgroundEpithelial-to-mesenchymal transition (EMT), which involves changes in cellular morphology of highly polarized epithelial cells and the gain of mesenchymal cell phenotype with migratory and invasive capacities, is implicated in smoking-related chronic obstructive pulmonary disease (COPD). However, the interactions of fibroblasts and epithelial cells and the participation of fibroblasts in the EMT processes in COPD are poorly …
Authors
Nishioka M; Venkatesan N; Dessalle K; Mogas A; Kyoh S; Lin T-Y; Nair P; Baglole CJ; Eidelman DH; Ludwig MS
Journal
Respiratory Research, Vol. 16, No. 1,
Publisher
Springer Nature
Publication Date
December 2015
DOI
10.1186/s12931-015-0232-4
ISSN
1465-9921