Journal article
Induction of micronucleated and binucleate cells in Chinese hamster ovary (CHO) cells by cis-diamminedichloroplatinum (II): a morphological and morphometric study
Abstract
The mutagenicity and cytotoxicity of cis-diamminedichloroplatinum (II) (cisplatin) at doses of 5, 10 and 20 micrograms/ml in Chinese hamster ovary (CHO) cells have been examined. A morphological characterization of several cell types induced by cisplatin was carried out. The frequencies of both cells with micronuclei and binucleate cells as a time-dependent parameter have also been studied. Whilst the number of cells with micronuclei was found …
Authors
Rodilla V; Pellicer JA; Pertusa J; Mothersill C
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 241, No. 2, pp. 115–124
Publisher
Elsevier
Publication Date
June 1990
DOI
10.1016/0165-1218(90)90114-h
ISSN
0027-5107