Journal article
The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis
Abstract
CE coupled with UV detection was assessed as a possible platform for the chemical identity and purity analysis of positron emission tomography (PET) tracers using [(18)F]FAC and [(18)F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities, as well as real radioactive samples (formulated for injection), were analyzed. Using MEKC with SDS in a neutral phosphate buffer, the separation of all …
Authors
Cheung S; Ly J; Lazari M; Sadeghi S; Keng PY; van Dam RM
Journal
Journal of Pharmaceutical and Biomedical Analysis, Vol. 94, , pp. 12–18
Publisher
Elsevier
Publication Date
June 2014
DOI
10.1016/j.jpba.2014.01.023
ISSN
0731-7085