Journal article
A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice
Abstract
We investigated the effects of a novel multi-ingredient supplement comprised of polyphenol antioxidants and compounds known to facilitate mitochondrial function and metabolic enhancement (ME) in a mouse model of obesity. In this study, 6-week-old male C57/BL6J mice were placed on a high-fat diet (HFD; ~60% fat) for 6 weeks, with subsequent allocation into experimentalgroups for 4 weeks: HFD control, HFD + ME10 (10 components), HFD + ME7 (7 …
Authors
Nederveen JP; Manta K; Bujak AL; Simone AC; Fuda MR; Nilsson MI; Hettinga BP; Hughes MC; Perry CGR; Tarnopolsky MA
Journal
Nutrients, Vol. 13, No. 11,
Publisher
MDPI
DOI
10.3390/nu13113726
ISSN
2072-6643
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipose Tissue, BrownAdipose Tissue, WhiteAnimalsAntioxidantsBiomarkersBlood CirculationCell RespirationDiet, High-FatDietary SupplementsEpididymisFeeding BehaviorLipid MetabolismMaleMice, Inbred C57BLMitochondriaMitochondrial ProteinsOrganelle BiogenesisOxidation-ReductionOxidative PhosphorylationPhosphorylationPhysical Conditioning, AnimalRNA, MessengerSuperoxide DismutaseUp-RegulationWeight GainWeight LossMice