Levetiracetam vs phenytoin prophylaxis in severe traumatic brain injury: Systematic review and meta-analysis

Background Prophylaxis against seizures has been recommended in the guidelines for severe traumatic brain injury. Levetiracetam has been suggested as an alternative pharmacotherapy to phenytoin due to more favorable side effects profile. The aim of this study is to compare the evidence for levetiracetam versus phenytoin for the prophylaxis of early seizures after severe brain trauma. Methods We searched the EMBASE, MEDLINE and COCHRANE …