Journal article
Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.
Abstract
OBJECTIVE: Methotrexate (MTX) is one of the most commonly used anti-cancer drugs for various types of neoplasms. It is associated with multiple cytotoxic effects including nephrotoxicity, hepatotoxicity and cardiotoxicity. Liraglutide (LIR) is a potent anti-diabetic drug and also has antioxidant and anti-inflammatory properties. In this study, we tried to investigate the protective effect of LIR on MTX induced cardiotoxicity and to identify the …
Authors
Mahmoud RH; Mohammed MA; Said ES; Morsi EM; Abdelaleem OO; Abdel All MO; Elsayed RM; Abdelmeguid EA; Eldosoki DE
Journal
European review for medical and pharmacological sciences, Vol. 25, No. 19, pp. 6013–6024
Publication Date
October 2021
DOI
10.26355/eurrev_202110_26879
ISSN
1128-3602