Journal article
O06 Methadone dosing strategies in preterm neonates can be simplified
Abstract
Aims
A dramatic increase in newborn infants with neonatal abstinence syndrome has been observed and these neonates are frequently treated with complex methadone dosing schemes to control their withdrawal symptoms. Despite its abundant use, hardly any data on the pharmacokinetics of methadone is available in preterm neonates. Therefore we investigated developmental pharmacokinetics of methadone and evaluated current dosing …
Authors
van Donge T; Samiee-Zafarghandy S; Pfister M; Koch G; Kalani M; Bordbar A; van den Anker J
Journal
Archives of Disease in Childhood, Vol. 104, No. 6,
Publisher
BMJ
Publication Date
June 2019
DOI
10.1136/archdischild-2019-esdppp.6
ISSN
0003-9888