Journal article
Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) – study protocol for a randomised controlled trial
Abstract
BACKGROUND: Inflammation contributes to unstable atherosclerotic plaque and stroke. In randomised trials in patients with coronary disease, canukinumab (an interleukin-1B antagonist) and colchicine (a tubulin inhibitor with pleiotropic anti-inflammatory effects) reduced recurrent vascular events.Hypothesis: Anti-inflammatory therapy with low-dose colchicine plus usual care will reduce recurrent vascular events in patients with non-severe, …
Authors
Kelly P; Weimar C; Lemmens R; Murphy S; Purroy F; Arsovska A; Bornstein NM; Czlonkowska A; Fischer U; Fonseca AC
Journal
European Stroke Journal, Vol. 6, No. 2, pp. 222–228
Publisher
SAGE Publications
Publication Date
June 2021
DOI
10.1177/2396987320972566
ISSN
2396-9873