Journal article
MEDU-44. MUSASHI-1 IS A MASTER REGULATOR OF ABERRANT TRANSLATION IN GROUP 3 MEDULLOBLASTOMA
Abstract
Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with group 3 (G3) MB representing the poorest prognostic subgroup with a remarkable ability to resist upfront multimodal therapy. Despite a low mutational burden of disease and MYC amplification identified as a independent factor associated with poor survivorship, efforts to target MYC or the MYC-MAX complex has met with limited therapeutic success. Consequently …
Authors
Kameda-Smith M; Brown K; Zhu H; Luo E; Yee B; Xing S; Venugopal C; van Nostrand E; Bakhshinyan D; Subapanditha M
Journal
Neuro-Oncology, Vol. 21, No. Supplement_2, pp. ii112–ii113
Publisher
Oxford University Press (OUP)
Publication Date
April 23, 2019
DOI
10.1093/neuonc/noz036.202
ISSN
1522-8517