Journal article
MBRS-01. DISSECTING REGULATORS OF THE ABERRANT POST-TRANSCRIPTIONAL LANDSCAPE IN MYC-AMPLIFIED GROUP 3 MEDULLOBLASTOMA
Abstract
Abstract
Medulloblastoma (MB) is the most common solid malignant pediatric brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of the MYC pathway remains limited and alternative therapies for G3 MB are urgently needed. Here we show that an RNA-binding protein, Musashi-1 (MSI1) is an essential mediator …
Authors
Kameda-Smith M; Zhu H; Luo E; Venugopal C; Xella A; Brown K; Fox R; Yee B; Xing S; Tan F
Journal
Neuro-Oncology, Vol. 22, No. Supplement_3, pp. iii399–iii399
Publisher
Oxford University Press (OUP)
Publication Date
December 4, 2020
DOI
10.1093/neuonc/noaa222.522
ISSN
1522-8517