Journal article
Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci
Abstract
The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling molecules that are able to interfere with the staphylococcal quorum-sensing system agr, a key regulator of virulence genes, and …
Authors
Li J; Wang W; Xu SX; Magarvey NA; McCormick JK
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 8, pp. 3360–3365
Publisher
Proceedings of the National Academy of Sciences
Publication Date
February 22, 2011
DOI
10.1073/pnas.1017431108
ISSN
0027-8424