Journal article
A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
Abstract
A new line in antibioticsAndrimid is a hybrid nonribosomal peptide-polyketide antibiotic that has been isolated from several different types of bacteria in the past twenty years. It is a nanomolar inhibitor of bacterial acetyl-CoA carboxylase, and inhibiting this enzyme blocks a step in prokaryotic fatty acid biosynthesis. Fortin et al. now show that AdmF, one of the enzymes responsible for the biosynthesis of andrimid, is a …
Authors
Fortin PD; Walsh CT; Magarvey NA
Journal
Nature, Vol. 448, No. 7155, pp. 824–827
Publisher
Springer Nature
Publication Date
August 16, 2007
DOI
10.1038/nature06068
ISSN
0028-0836