Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study

BACKGROUND: Emerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (SN) and it may reflect patient-specific trait of Parkinson's Disease (PD). We assume it could account for variability in motor outcome of subthalamic nucleus deep brain stimulation (STN-DBS) in PD. OBJECTIVE: To investigate whether SN susceptibility features derived from radiomics with machine learning (RA-ML) can predict motor outcome …