Two-locus, fourth-order gene frequency moments: Implications for the variance of squared linkage disequilibrium and the variance of homozygosity

Identity coefficients are used to construct a sufficient set of equations to determine the fourth-order moments of gene frequencies for two linked loci. This allows the variance of the expected squared linkage disequilibrium to be found. It is shown that the coefficient of variation is generally greater than one and if the mutation rate is small, the standard deviation is more than four times the size of the mean. This demonstrates that squared …