Journal article
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
Abstract
Mitochondria form a complex, interconnected reticulum that is maintained through coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in response to various cues to maintain energetic homeostasis. These cellular events, which make up mitochondrial quality control, act with remarkable spatial precision, but what governs such spatial specificity is poorly understood. Herein, we demonstrate that specific …
Authors
Drake JC; Wilson RJ; Laker RC; Guan Y; Spaulding HR; Nichenko AS; Shen W; Shang H; Dorn MV; Huang K
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 37,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
September 14, 2021
DOI
10.1073/pnas.2025932118
ISSN
0027-8424