Journal article
Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4
Abstract
Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics, prebiotics, or probiotics can be limited by specificity or sustained changes in microbial composition. Postbiotics include bacterial components such as lipopolysaccharides, which have been shown to promote insulin resistance during metabolic endotoxemia. We found that bacterial cell wall-derived muramyl dipeptide (MDP) is an insulin-sensitizing …
Authors
Cavallari JF; Fullerton MD; Duggan BM; Foley KP; Denou E; Smith BK; Desjardins EM; Henriksbo BD; Kim KJ; Tuinema BR
Journal
Cell Metabolism, Vol. 25, No. 5, pp. 1063–1074.e3
Publisher
Elsevier
Publication Date
5 2017
DOI
10.1016/j.cmet.2017.03.021
ISSN
1550-4131