Journal article
Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects: Systematic Review and Meta-regression Analysis
Abstract
CONTEXT: Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping.
OBJECTIVE: To compare the treatment effect from truncated RCTs with that from meta-analyses of RCTs addressing the same question but not stopped early (nontruncated RCTs) and to explore factors associated with overestimates of …
Authors
Bassler D; Briel M; Montori VM; Lane M; Glasziou P; Zhou Q; Heels-Ansdell D; Walter SD; Guyatt GH; Flynn DN
Journal
JAMA: The Journal of the American Medical Association, Vol. 303, No. 12, pp. 1180–1187
Publisher
American Medical Association (AMA)
Publication Date
March 24, 2010
DOI
10.1001/jama.2010.310
ISSN
0098-7484