Scholarly Works

Isolation of DNA Aptamers for CDP‐Ribitol...

Journal article

Isolation of DNA Aptamers for CDP‐Ribitol Synthase, and Characterization of Their Inhibitory and Structural Properties

Abstract

Two birds with one stone: Four DNA aptamers were isolated for Bcs1, a bifunctional enzyme that catalyzes both the reduction of ribulose 5‐phosphate by using NADPH and cytidylyltransfer by using CTP. The inhibitory effects of these aptamers towards Bcs1 and their secondary structural properties were investigated (see scheme).

Authors

Allali‐Hassani A; Pereira MP; Navani NK; Brown ED; Li Y

Journal

ChemBioChem, Vol. 8, No. 17, pp. 2052–2057

Publisher

Wiley

Publication Date

November 23, 2007

DOI

10.1002/cbic.200700257

ISSN

1439-4227

Associated Experts

Eric Brown

Professor, Faculty of Health Sciences

Yingfu Li

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3101 Biochemistry and cell biology 31 Biological Sciences 3404 Medicinal and biomolecular chemistry

Medical Subject Headings (MeSH)

Aptamers, Nucleotide Inhibitory Concentration 50 Molecular Sequence Data Molecular Structure Mutation Nucleoside Diphosphate Sugars Transferases (Other Substituted Phosphate Groups)

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