An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

Although general inhibitors of the ubiquitin-proteasome system have been reported, compounds targeting specific ubiquitylation enzymes should be beneficial in clinical applications and basic research. Orlicky et al. present an allosteric inhibitor specific to the yeast SCFCdc4 E3 ligase that prevents binding of the target protein to the WD40 domain of the complex.