Journal article
AMPK β1 reduces tumor progression and improves survival in p53 null mice
Abstract
The AMP-activated protein kinase (AMPK) is a heterotrimeric protein complex that is an important sensor of cellular energy status. Reduced expression of the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this accelerates tumor progression and the potential mechanism mediating these effects are not known. Furthermore, it is unknown whether AMPK β1 is implicated in tumorigenesis, and if so, what tissues may …
Authors
Houde VP; Donzelli S; Sacconi A; Galic S; Hammill JA; Bramson JL; Foster RA; Tsakiridis T; Kemp BE; Grasso G
Journal
Molecular Oncology, Vol. 11, No. 9, pp. 1143–1155
Publisher
Wiley
Publication Date
9 2017
DOI
10.1002/1878-0261.12079
ISSN
1574-7891