Journal article
Immune Inhibitory Ligand CD200 Induction by TLRs and NLRs Limits Macrophage Activation to Protect the Host from Meningococcal Septicemia
Abstract
Macrophage activation is essential for protection against bacterial pathogens but needs to be regulated to prevent damage to the host. We show a key role for the immune inhibitory receptor CD200R and its ligand CD200 in the context of infection with the Gram-negative human pathogen Neisseria meningitidis. N. meningitidis induced CD200 but downregulated CD200R on macrophages in a manner dependent on Neisserial lipopolysaccharide, Toll-like …
Authors
Mukhopadhyay S; Plüddemann A; Hoe JC; Williams KJ; Varin A; Makepeace K; Aknin M-L; Bowdish DME; Smale ST; Barclay AN
Journal
Cell Host & Microbe, Vol. 8, No. 3, pp. 236–247
Publisher
Elsevier
Publication Date
September 2010
DOI
10.1016/j.chom.2010.08.005
ISSN
1931-3128
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntigens, CDCarrier ProteinsCytokinesEnzyme-Linked Immunosorbent AssayFlow CytometryGene Expression RegulationHumansLipopolysaccharidesMacrophage ActivationMacrophages, PeritonealMembrane GlycoproteinsMeningococcal InfectionsMiceMyeloid Differentiation Factor 88NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNeisseria meningitidisNod2 Signaling Adaptor ProteinPeritonitisSepsisSignal TransductionToll-Like Receptor 4Toll-Like Receptors