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Class A Scavenger Receptor–Mediated...
Journal article

Class A Scavenger Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity

Abstract

dsRNA is a potent trigger of innate immune signaling, eliciting effects within virally infected cells and after release from dying cells. Given its inherent stability, extracellular dsRNA induces both local and systemic effects. Although the class A scavenger receptors (SR-As) mediate dsRNA entry, it is unknown whether they contribute to signaling beyond ligand internalization. In this study, we investigated whether SR-As contribute to innate …

Authors

Nellimarla S; Baid K; Loo Y-M; Gale M; Bowdish DME; Mossman KL

Journal

The Journal of Immunology, Vol. 195, No. 8, pp. 3858–3865

Publisher

Oxford University Press (OUP)

Publication Date

October 15, 2015

DOI

10.4049/jimmunol.1501028

ISSN

0022-1767