Journal article
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Abstract
BACKGROUND: Functional copy number variation in the apolipoprotein(a) gene (LPA) underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein(a) [Lp(a)] particle. Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed.
METHODS AND RESULTS: First, we genotyped 49 SNPs within 100 kb of LPA in a multiethnic sample comprising …
Authors
Lanktree MB; Anand SS; Yusuf S; Hegele RA
Journal
Circulation Genomic and Precision Medicine, Vol. 3, No. 1, pp. 39–46
Publisher
Wolters Kluwer
Publication Date
February 2010
DOI
10.1161/circgenetics.109.907642
ISSN
1942-325X