Diminished contraction‐induced intracellular signaling in aged fast‐twitch skeletal muscle with low and high mitochondrial content

Reduced plasticity of senescent skeletal muscle may be due to an attenuated signaling response to contractions. The intent of the present study was to determine whether aging affects signaling pathways involved in mitochondrial biogenesis in response to a single bout of contractile activity (CA). Acute stimulation (1 Hz, 5 min) of the tibialis anterior (TA) resulted in a significantly greater rate of fatigue in 36 month (mo) relative to 6 mo …