Journal article
The impact of maternal synthetic glucocorticoid administration in late pregnancy on fetal and early neonatal hypothalamic–pituitary–adrenal axes regulatory genes is dependent upon dose and gestational age at exposure
Abstract
In this study, we determined the gene and/or protein expression of hypothalamic-pituitary-adrenal (HPA) axis regulatory molecules following synthetic glucocorticoid exposures. Pregnant sheep received intramuscular saline or betamethasone (BET) injections at 104 (BET-1), 104 and 111(BET-2) or 104, 111 and 118 (BET-3) days of gestation (dG). Samples were collected at numerous time-points between 75 dG and 12 weeks postnatal age. In the BET-3 …
Authors
Li S; Moss TJM; Nitsos I; Matthews SG; Challis JRG; Newnham JP; Sloboda DM
Journal
Journal of Developmental Origins of Health and Disease, Vol. 4, No. 1, pp. 77–89
Publisher
Cambridge University Press (CUP)
Publication Date
2 2013
DOI
10.1017/s2040174412000591
ISSN
2040-1744
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3-Hydroxysteroid DehydrogenasesAge FactorsAnimalsAnimals, NewbornBetamethasoneDose-Response Relationship, DrugFemaleFetusGene Expression RegulationGestational AgeGlucocorticoidsHydrocortisoneHypothalamo-Hypophyseal SystemPhosphoproteinsPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsReceptors, CorticotropinSheepSteroidogenic Acute Regulatory Protein