Journal article
Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study
Abstract
BACKGROUND: Metabolic abnormalities that lead to type 2 diabetes mellitus begin in early childhood.
OBJECTIVES: We investigate whether common genetic variants identified in adults have an effect on glucose in early life.
Authors
Sohani ZN; Anand SS; Robiou-du-Pont S; Morrison KM; McDonald SD; Atkinson SA; Teo KK; Meyre D
Journal
PLOS ONE, Vol. 11, No. 4,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0152107
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenylyl CyclasesAdultAllelesBlood GlucoseChild, PreschoolCyclin-Dependent Kinase 5Cyclin-Dependent Kinase Inhibitor p15Diabetes Mellitus, Type 2FemaleGRB10 Adaptor ProteinGenes, p16Genetic Predisposition to DiseaseHumansInfantInfant, NewbornMalePolymorphism, Single NucleotideQuantitative Trait LociReceptors, Adrenergic, alpha-2tRNA Methyltransferases