Journal article
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
Abstract
Aims/hypothesisInflammation in obesity increases the levels of the suppressor of cytokine signalling-3 (SOCS3) protein in adipose tissue, but the physiological importance of this protein in regulating whole-body insulin sensitivity in obesity is not known.MethodsWe generated Socs3 floxed (wild-type, WT) and Socs3 aP2 (also known as Fabp4)-Cre null (Socs3 AKO) mice. Mice were maintained on either a regular chow or a high-fat diet (HFD) for …
Authors
Palanivel R; Fullerton MD; Galic S; Honeyman J; Hewitt KA; Jorgensen SB; Steinberg GR
Journal
Diabetologia, Vol. 55, No. 11, pp. 3083–3093
Publisher
Springer Nature
Publication Date
11 2012
DOI
10.1007/s00125-012-2665-3
ISSN
0012-186X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipose TissueAnimalsBlood GlucoseDietary FatsEnergy MetabolismFemaleGlucose IntoleranceInflammationInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutObesityOxygen ConsumptionPhosphorylationSex FactorsSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling Proteins