Journal article
Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function
Abstract
Lipid nanoparticles (LNPs) composed of ionizable cationic lipids are currently the leading systems for siRNA delivery in liver disease, with the major limitation of low siRNA release efficacy into the cytoplasm. Ionizable cationic lipids are known to be of critical importance in LNP structure and stability, siRNA entrapment, and endosomal disruption. However, their distribution inside the LNPs and their exact role in cytoplasmic delivery remain …
Authors
Ramezanpour M; Schmidt ML; Bodnariuc I; Kulkarni JA; Leung SSW; Cullis PR; Thewalt JL; Tieleman DP
Journal
Nanoscale, Vol. 11, No. 30, pp. 14141–14146
Publisher
Royal Society of Chemistry (RSC)
Publication Date
August 1, 2019
DOI
10.1039/c9nr02297j
ISSN
2040-3364