Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device

PEGylated proteins comprise a class of value-added biopharmaceuticals. High-resolution separation techniques are required for the purification of these molecules. In this study, we discuss the application of a newly developed z² laterally-fed membrane chromatography (or z²LFMC) device for carrying out high-resolution purification of a PEGylated protein drug. The device used in the current study contained a stack of anion exchange (Q) membranes. …