Journal article
Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli
Abstract
Apoptosis can be evoked by reactive oxygen species (ROS)-induced mitochondrial release of the proapoptotic factors cytochrome c and apoptosis-inducing factor (AIF). Because skeletal muscle is composed of two mitochondrial subfractions that reside in distinct subcellular regions, we investigated the apoptotic susceptibility of subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria. SS and IMF mitochondria exhibited a dose-dependent release …
Authors
Adhihetty PJ; Ljubicic V; Menzies KJ; Hood DA
Journal
American Journal of Physiology - Cell Physiology, Vol. 289, No. 4, pp. c994–c1001
Publisher
American Physiological Society
Publication Date
10 2005
DOI
10.1152/ajpcell.00031.2005
ISSN
0363-6143