Journal article
A new method for measurement of total plasma PCSK9: clinical applications
Abstract
The proprotein convertase subtilisin kexin-9 (PCSK9) circulates in plasma as mature and furin-cleaved forms. A polyclonal antibody against human PCSK9 was used to develop an ELISA that measures total plasma PCSK9 rather than only the mature form. A cross-sectional study evaluated plasma levels in normal (n = 254) and hypercholesterolemic (n = 200) subjects treated or untreated with statins or statin plus ezetimibe. In controls, mean plasma …
Authors
Dubuc G; Tremblay M; Paré G; Jacques H; Hamelin J; Benjannet S; Boulet L; Genest J; Bernier L; Seidah NG
Journal
Journal of Lipid Research, Vol. 51, No. 1, pp. 140–149
Publisher
Elsevier
Publication Date
1 2010
DOI
10.1194/jlr.m900273-jlr200
ISSN
0022-2275
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AntibodiesAzetidinesBlood GlucoseCell LineCholesterolCholesterol, LDLCross-Sectional StudiesDrug MonitoringEnzyme-Linked Immunosorbent AssayEzetimibeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipoproteinemia Type IIProprotein Convertase 9Proprotein ConvertasesSerine EndopeptidasesTriglycerides