Journal article
Novel Loci, Including Those Related to Crohn Disease, Psoriasis, and Inflammation, Identified in a Genome-Wide Association Study of Fibrinogen in 17 686 Women
Abstract
BACKGROUND: Fibrinogen is a multifunctional circulating glycoprotein involved in wound healing, thrombosis, platelet aggregation, and inflammation, and elevated levels predict vascular disease. Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available.
METHODS AND RESULTS: To address this issue, we undertook a genome-wide association …
Authors
Danik JS; Paré G; Chasman DI; Zee RYL; Kwiatkowski DJ; Parker A; Miletich JP; Ridker PM
Journal
Circulation Genomic and Precision Medicine, Vol. 2, No. 2, pp. 134–141
Publisher
Wolters Kluwer
Publication Date
4 2009
DOI
10.1161/circgenetics.108.825273
ISSN
1942-325X