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Hundreds of variants clustered in genomic loci and...
Journal article

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Abstract

The genetics of human heightA genome-wide association (GWA) study of more than 180,000 individuals has identified hundreds of genetic variants in at least 180 loci associated with adult human height. The loci are not clustered randomly but are enriched for genes involved in growth-related processes that influence adult height. This demonstrates that GWA studies of common human traits, and therefore of many diseases, can identify large numbers of loci that implicate potential causal genes.

Authors

Lango Allen H; Estrada K; Lettre G; Berndt SI; Weedon MN; Rivadeneira F; Willer CJ; Jackson AU; Vedantam S; Raychaudhuri S

Journal

Nature, Vol. 467, No. 7317, pp. 832–838

Publisher

Springer Nature

Publication Date

October 14, 2010

DOI

10.1038/nature09410

ISSN

0028-0836

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