Journal article
Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome
Abstract
BackgroundAlpha thalassemia/mental retardation X-linked syndrome (ATR-X) is caused by a mutation at the chromatin regulator gene ATRX. The mechanisms involved in the ATR-X pathology are not completely understood, but may involve epigenetic modifications. ATRX has been linked to the regulation of histone H3 and DNA methylation, while mutations in the ATRX gene may lead to the downstream epigenetic and transcriptional effects. Elucidating the …
Authors
Schenkel LC; Kernohan KD; McBride A; Reina D; Hodge A; Ainsworth PJ; Rodenhiser DI; Pare G; Bérubé NG; Skinner C
Journal
Epigenetics & Chromatin, Vol. 10, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s13072-017-0118-4
ISSN
1756-8935