Journal article
Chronic Graft Versus Host Disease Is Associated With an Immune Response to Autologous Human Leukocyte Antigen–Derived Peptides
Abstract
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic bone marrow transplantation (BMT) the immunopathogenesis of which is not well understood. Humoral and cellular immunity are both implicated, patients express a range of autoantibodies, but the targets of cellular immunity are not well defined. Autologous human leukocyte antigen (HLA)-derived peptides constitute a significant proportion of the repertoire.
Authors
Smith HJ; Hanvesakul R; Morgan MD; Bentall A; Briggs D; Clark F; Pratt G; Moss P; Larché M; Ball S
Journal
Transplantation, Vol. 90, No. 5, pp. 555–563
Publisher
Wolters Kluwer
Publication Date
September 15, 2010
DOI
10.1097/tp.0b013e3181e86b58
ISSN
0041-1337