Journal article
T Lymphocyte Responses to Nonpolymorphic HLA-Derived Peptides Are Associated With Chronic Renal Allograft Dysfunction
Abstract
BACKGROUND: The routine assessment of cellular alloimmunity to guide therapy is of perennial interest because this limb of the immune system is the main target of current transplant immunosuppression. That this has not as yet been realized in clinical practice reflects the difficulty of developing a standardized assay that accounts for the high degree of polymorphism exhibited by histocompatibility antigens.
METHODS: We have investigated …
Authors
Smith HJ; Hanvesakul R; Bentall A; Shabir S; Morgan MD; Briggs D; Cockwell P; Borrows R; Larché M; Ball S
Journal
Transplantation, Vol. 91, No. 3, pp. 279–286
Publisher
Wolters Kluwer
Publication Date
February 15, 2011
DOI
10.1097/tp.0b013e318203862d
ISSN
0041-1337
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultCD4-Positive T-LymphocytesCase-Control StudiesEnzyme-Linked Immunospot AssayEpitopesFemaleGraft RejectionHistocompatibility Antigens Class IHumansImmunity, CellularInterferon-gammaInterleukin-2 Receptor alpha SubunitInterleukin-7 Receptor alpha SubunitKidney TransplantationMaleMiddle AgedPeptidesRenal InsufficiencyTransplantation, Homologous