Journal article
Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy
Abstract
BACKGROUND: Induction of allergen-specific IgG(4) antibodies is the most consistent immunological finding in immunotherapy trials. However, quantitative assessments of IgG(4) antibodies have not proven beneficial in evaluating clinical changes during or after immunotherapy. In the current study, we investigated the relationship between clinical outcome and allergen-specific IgG(4) titres or functional antibody responses following immunotherapy. …
Authors
Shamji MH; Ljørring C; Francis JN; Calderon MA; Larché M; Kimber I; Frew AJ; Ipsen H; Lund K; Würtzen PA
Journal
Allergy, Vol. 67, No. 2, pp. 217–226
Publisher
Wiley
Publication Date
February 2012
DOI
10.1111/j.1398-9995.2011.02745.x
ISSN
0001-5148