Journal article
SDF-1 enhances the expansion and maintenance of highly purified human hematopoietic progenitors.
Abstract
The stromal-derived factor-1 (SDF-1) chemokine and its putative receptor, CXCR4, have been implicated in hematopoiesis. Here we aim to characterize the effects of cytokine-induced CXCR4 expression and SDF-1 treatment on primitive human umbilical cord blood (CB) cells in vitro. Highly purified CD34+CD38-Lin-CXCR4- blood cells were capable of forming CD34+CXCR4+ cells during short-term liquid culture, but maintained distinct erythroid and myeloid …
Authors
Rosu-Myles M; Bhatia M
Journal
Haematologica, Vol. 4, No. 2, pp. 137–145
Publisher
Springer Nature
Publication Date
2003
DOI
10.1038/sj.thj.6200233
ISSN
0390-6078