Journal article
Intra–bone marrow transplantation facilitates pauci-clonal human hematopoietic repopulation of NOD/SCID/β2m−/− mice
Abstract
OBJECTIVE: Intra-bone marrow transplantation (IBMT) has been shown to improve the limit of detection of primitive human SCID-repopulating cells (SRC) in NOD/SCID mice when compared to intravenous transplantation. We sought to further refine detection of SRC by comparing NOD/SCID mice to the more sensitive NOD/SCID/beta2m(-/-)strain as IBMT recipients of limiting numbers of purified primitive human hematopoietic cells.
MATERIALS AND METHODS: …
Authors
Levac K; Menendez P; Bhatia M
Journal
Experimental Hematology, Vol. 33, No. 11, pp. 1417–1426
Publisher
Elsevier
Publication Date
November 2005
DOI
10.1016/j.exphem.2005.07.007
ISSN
0301-472X