Conference
Abstract 1107: β2-integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.
Abstract
Abstract
Constitutive activation of certain kinase-dependent signal transduction pathways is critical for the pathogenesis of acute myeloid leukemia (AML). Apart from FLT3-ITD the spleen tyrosine kinase (Syk) induces cell survival and proliferation in a high proportion of AML blasts, but the underlying molecular events of Syk signaling have not been investigated so far. Using a phosphoproteomic approach we elucidated the …
Authors
Oellerich T; Oellerich M; Engelke M; Muench S; Mohr S; Hsiao H-H; Zhang J; Bohnenberger H; Berg T; Rieger M
Volume
73
Pagination
pp. 1107-1107
Publisher
American Association for Cancer Research (AACR)
Publication Date
April 15, 2013
DOI
10.1158/1538-7445.am2013-1107
Conference proceedings
Cancer Research
Issue
8_Supplement
ISSN
0008-5472