Conference
AML1/ETO Expresssion in Myeloid Leukemia Cells Is Associated with Enhanced Growth-Inhibitory and P15/INK4b Demethylating Effects of 5-AZA-2′-Deoxycytidine.
Abstract
Abstract
The chromosomal translocation (8;21) results in the expression of the chimeric transcription factor AML1/ETO, the most frequent fusion gene in acute myeloid leukemia. The AML1/ETO fusion protein acts as a transcriptional repressor by mediating epigenetic silencing through recruitment of histone deacetylases. Recently, it was shown that it also mediates gene silencing by associating with DNA methyltransferase (Dnmt). …
Authors
Berg T; Abdelkarim M; Guo Y; Fliegauf M; Lübbert M
Volume
104
Publisher
American Society of Hematology
Publication Date
November 16, 2004
DOI
10.1182/blood.v104.11.1165.1165
Conference proceedings
Blood
Issue
11
ISSN
0006-4971