Journal article
Direct conversion of human fibroblasts to multilineage blood progenitors
Abstract
As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together …
Authors
Szabo E; Rampalli S; Risueño RM; Schnerch A; Mitchell R; Fiebig-Comyn A; Levadoux-Martin M; Bhatia M
Journal
Nature, Vol. 468, No. 7323, pp. 521–526
Publisher
Springer Nature
Publication Date
11 2010
DOI
10.1038/nature09591
ISSN
0028-0836