Journal article
Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs
Abstract
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell types. However, the composition and role of the human BM HSC niche have not been investigated. Here, using human bone biopsy specimens, we provide evidence of HSC propensity to localize to endosteal regions of the trabecular bone area (TBA). Through functional …
Authors
Guezguez B; Campbell CJV; Boyd AL; Karanu F; Casado FL; Di Cresce C; Collins TJ; Shapovalova Z; Xenocostas A; Bhatia M
Journal
Cell Stem Cell, Vol. 13, No. 2, pp. 175–189
Publisher
Elsevier
Publication Date
August 2013
DOI
10.1016/j.stem.2013.06.015
ISSN
1934-5909