Journal article
Capicua is a fast-acting transcriptional brake
Abstract
Even though transcriptional repressors are studied with ever-increasing molecular resolution, the temporal aspects of gene repression remain poorly understood. Here, we address the dynamics of transcriptional repression by Capicua (Cic), which is essential for normal development and is commonly mutated in human cancers and neurodegenerative diseases.1,2 We report the speed limit for Cic-dependent gene repression based on live imaging and …
Authors
Patel AL; Zhang L; Keenan SE; Rushlow CA; Fradin C; Shvartsman SY
Journal
Current Biology, Vol. 31, No. 16, pp. 3639–3647.e5
Publisher
Elsevier
Publication Date
8 2021
DOI
10.1016/j.cub.2021.05.061
ISSN
0960-9822