Journal article
Antibiotic use and outcomes with systemic therapy in metastatic renal cell carcinoma (mRCC).
Abstract
607
Background: Antibiotic (Abx) use is shown to alter commensal gut microbiota, a key regulator of immune homeostasis. We conducted the largest investigation to date on the impact of Abx use on outcomes in mRCC patients treated with systemic agents. Methods: Two cohorts were analyzed: an institutional cohort (DFCI, n = 146) of patients receiving PD-1/PD-L1-based immune checkpoint inhibitors (ICI), and an external cohort from …
Authors
Lalani A-KA; Xie W; Lin X; Steinharter JA; Martini DJ; Duquette A; Bosse D; McKay RR; Simantov R; Wei XX
Journal
Journal of Clinical Oncology, Vol. 36, No. 6_suppl, pp. 607–607
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
February 20, 2018
DOI
10.1200/jco.2018.36.6_suppl.607
ISSN
0732-183X